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Director, Head of Recombinant Protein Discovery

Location
Marburg, Hessen
Job Type
Permanent
Posted
3 Sep 2022

Position Purpose

The Director of the Recombinant Protein Discovery Group Marburg will have operational leadership responsibility for activities undertaken within the group for which she / he will provide scientific and quality expertise and guidance. The incumbent will manage the group to provide subject matter expert (SME) expertise in the area of antibody discovery (phage and/or other methods of protein display), protein expression and purification (USP / DSP), and biophysical QC of biotherapeutics (PAGE, SEC, SLS, DLS etc.).

The incumbent is responsible for managing sub-teams (mAb/USP/DSP) run by senior managers that will consist of senior scientists, scientists & technicians. The ability to lead, motivate, train and develop staff are important elements of this position. The incumbent is expected to hire and develop talent in line with CSL's strategic objectives and therapeutic areas (TAs,  mainly Hematology, Respiratory, and Immunology.

The incumbent is responsible for the seamless communication and alignment with CSL functions involved in the development of new biotherapeutics, mainly the Antibody Discovery and Protein Engineering (ADPE) group and recombinant expression and purification groups in Melbourne, Marburg or Bern.

In addition, the incumbent will be responsible for ensuring the laboratory keeps abreast of new technologies and approaches and strategically employs these to increase quality, and throughput of new potential biotherapeutics, co-ordinating with the Head of ADPE, based in Melbourne.

Responsibilities & Accountabilities

  • The incumbent will provide effective leadership and management of the group and build an effective team of skilled managers, scientists and technical staff in order to plan, resource, and execute tasks within the functional area. The incumbent will define and implement appropriate organizational structures (in consultation with the Senior Managers) and will recruit, develop, coach, and motivate staff. The incumbent will be responsible for adequate qualification and training within the group.

  • Together with the Head of Antibody Discovery and Protein Engineering (ADPE) in Melbourne, the incumbent will be responsible for expanding the group's current expertise (protein expression, purification and molecular biology) by effectively managing the staged tech transfer of the phage display antibody discovery capability from ADPE Melbourne to CSL's research site at Marburg.

  • The incumbent will oversee the development and the activities of the Recombinant Protein Discovery Marburg group, delegate tasks and projects, monitor adherence to budget consistent with agreed overall project objectives and timelines, and considering project prioritization as determined by the RPMC. Within the group, the incumbent will ensure the group uses and maintains state-of-the-art technologies and methods.

The incumbent will execute on CSL's objectives:

  • Supporting preclinical studies by engineering recombinant proteins including antibodies

  • Ensuring agreed targets for quality, timelines, costs, and user requirements are met

  • Planning work and resources

  • Providing full documentation of activities according to appropriate quality standards and in support of IP

  • Ensuring data integrity and scientific consistency in all experiments

  • Ensuring all labs and equipment are maintained in a state of operational readiness to meet quality standards and execute objectives against timelines

  • Ensuring experiments are performed in accordance with a robust scientific rationale, regulatory/internal guidelines, legal requirements and quality standards

  • Supervising the preparation, review and approval of study documentation (protocols, manuals and reports and relevant laboratory documents (e.g. SOPs)

  • The incumbent (or a delegate identified by the incumbent) will represent the group both internally and externally in areas relevant to their scientific and technical expertise and consistent with the activities being undertaken within the department. Potential external forums include regulatory agencies, collaborating academic and contract organizations, scientific symposia and conferences.

  • The incumbent will present results in English and German internally on local as well as global meetings. In addition, the incumbent is expected to proactively seek opportunities to generate new IP and to drive the preparation of manuscripts to increase CSL's scientific visibility.

  • The incumbent will provide effective and transparent communications to laboratory teams, equivalent function in Melbourne, colleagues, and other internal and external collaborators. The incumbent will collaborate with internal and global cross-functional expert teams and support efforts to ensure the coordination of activities and information between the functions and sites.

  • The incumbent ensures labs and facilities are operated according to all safety regulations and EHSS policies, actively supports the establishment of a "safety culture" and partners with EHSS to achieve local site safety targets.

Position Qualifications and Experience Requirements: 

  • A minimum of 10+ years relevant industry experience in a therapeutic protein engineering leadership role in a biological drug discovery environment

  • Demonstrated ability to lead highly effective scientific teams and work efficiently with employees and colleagues of all levels

  • Demonstrated ability to be independent and self-motivated

  • Substantial experience working in cross-functional, multicultural and international teams within a matrixed drug discovery environment

  • Demonstrated track record of high-quality scientific publications and/or patents related to therapeutic protein engineering and/or biological therapeutics

  • Excellent organizational and communication skills (English, German)

Our Benefits

We encourage you to make your well-being a priority. It's important and so are you. Learn more about how we care at CSL.

About CSL Behring

CSL Behring is a global leader in developing and delivering high-quality medicines that treat people with rare and serious diseases. Our treatments offer promise for people in more than 100 countries living with conditions in the immunology, hematology, cardiovascular and metabolic, respiratory, and transplant therapeutic areas. Learn more about CSL Behring .

We want CSL to reflect the world around us

As a global organisation with employees in 35+ countries, CSL embraces diversity and inclusion. Learn more about Diversity & Inclusion at CSL.

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Details

  • Job Reference: 703072935-2
  • Date Posted: 3 September 2022
  • Recruiter: CSL Behring
  • Location: Marburg, Hessen
  • Salary: On Application
  • Sector: Education
  • Job Type: Permanent